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January 2, 2006

Stem Cell Fraud

In the wake of the reports that a South Korean research scientist had faked his results has come a deluge of questions about scientific integrity and the value of peer review. The implication has been that peer review should have caught the fraud before publication. What good is science if it sometimes publishes things and then later takes it back?

This attitude demonstrates a misunderstanding of peer review and of science itself.

Science is not a club or a church. Science does not issue edicts or statements of truth in the way many seem to imagine. Just because a researcher has published some work does not mean that it comes with a stamp of veracity that all scientists sign on to.

BizzyBlog (and others) have come to terms with this during the course of this scandal, but have now raised a second concern (which I find completely legitimate): the effect of using taxpayer money to support researchers in uncertain scientific fields, such as stem cell research. If public money is spent without full understanding and disclosure, our public trust has been violated.

BizzyBlog's suggestion:

So the next time you hear the term “peer-reviewed,” I would substitute these words: “passed the smell test (maybe, and if the person submitting the work is ethical and conducted his/her work conscientiously and honorably).”
Given the ever-larger dollars, very often tax dollars, that are based on the reliability of scientific work, standards must be raised, even if it costs money up-front (auditors, if you will) to raise them, and even if scientists’ egos are bruised in the process.

Given that federal funds are being used I see the author's point, although I am too libertarian to support federal funds for stem cells or most other scientific research anyway. But even with federal expenditures in the field, these audits are not necessary if we all understand how science works, and what "peer review" actually means. BizzyBlog now outlines a December 30 WSJ article by Thomas Stossel, American Cancer Society Professor at Harvard Medical School and co-director of the division of hematology at Brigham and Women’s Hospital, who sums it up nicely:

If reporters understood that journals are magazines, not Holy Scripture, we might not be witnessing ever more onerous regulations inhibiting interactions between academic and industry science.

Also, Dr. Walter Witschey, director of the Science Museum of Virginia, has written an article (here) that hopes to explain the process of peer review for those who do not understand it. In layman's terms. I highly recomment it if you have never submitted a paper for publication in a scientific journal.

Wulf Posted by Wulf on January 2, 2006 at 10:05 AM

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Comments

I think Witschey's description of the process is fine, but his "Scientists use the peer-review process to assure us, as best possible, that their work is bona fide" is a bit generous, given what has happened. Either that or the "best" in "best as possible" really isn't that good.

Posted by: Tom Blumer at January 2, 2006 10:28 AM


I think a course in ethics should be a required course for scientists either as an undergrad or, even better, as in grad school.

It would seem that it would make sense. Though I have not taken one, and I do not believe that any of my friends that have just completed their Masters were in a scientific ethics classroom ever. But, I do recall a Prof. suggesting that an ethics class would be a good idea.

Posted by: Geoff at January 2, 2006 10:36 AM



A fair point, Tom. But Witschey's point is that peer review is not a stamp of validity. Some researchers are disingenuous in their attempt to assure us that their work is bona fide. But this is true in any industry. It is always up to the general scientific community (and financiers) to determine how much value the work holds. Any claim should be viewed with skepticism until it has been reproduced, even if it has passed peer review.

Posted by: Wulf at January 2, 2006 11:01 AM


I agree about the ethics course. I was required to take a course in ethics as an undergrad... but it was the same requirement that everybody else had to take at my college. There was no specific course about the ethics of research science. It was expected that we would sort of "pick it up" as a part of our labs and by the example of other scientists, maybe as grad students. Of course, some of us were more ethical than others. The reward of a higher grade is enough to entice some to unethical behavior, and it is not seen by most students as a big deal. But this then carries on to the real world, where scientists are competing for other rewards besides grades (prestige, financing, etc.).

Posted by: Wulf at January 2, 2006 11:02 AM


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