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Fifteen years ago this month, the first Gulf War began. Shortly thereafter, US troops began experiencing a "mystery illness" that still has not been identified - just labeled. Roughly a quarter of deployed vets complained of the symptoms that came to be known as "chronic multisymptom illness" (CMI). Listen here to a story that aired on NPR last week on the fact that veterans still show symptoms, and scientists still can't figure out exactly what or why.
As the story notes, many critics have claimed that "Gulf War Syndrome" is not real - they attributed it to war time stress. In November, an article in the American Journal of Epidemiology noted:
CMI continues to be substantially more prevalent among deployed veterans than among nondeployed veterans 10 years after Gulf War I, but it manifests similarly in both groups. It is likely to be a common, persistent problem among veterans returning from the current Gulf War.
But troops serving in Iraq today are not experiencing the same problems after all, despite the greater level of stress in this deployment (longer period, multiple tours of duty, higher casualty rate, insurgent attacks, etc.). There is of course disagreement about why this is the case, but hopefully we will find out.
Listen to Joseph Shapiro's follow-up story on NPR here.
UPDATE: I am not exactly sure what to make of this:
Veterans of the first Persian Gulf War suffering from medically unexplained fatigue associated with Gulf War Syndrome may have a genetic predisposition for developing the condition, geneticists at the University at Buffalo have found.
If true, this is fascinating research with huge implications.
Their research, involving healthy veterans and veterans with severe and chronic fatigue, as well as non-veterans with chronic fatigue syndrome, showed that affected veterans, in comparison with healthy controls, had an increased frequency of a nonbeneficial genetic variant in a gene involved in the production of angiotension-converting-enzyme (ACE), an enzyme important in the control of blood pressure and electrolyte balance.
Unexpectedly, the nonbeneficial variant was less common among non-veterans with symptoms identical to those of Gulf War Syndrome, indicating that the genetic variant rendered the carriers more susceptible to triggers present in the Gulf-War environment.
Results were reported in the July issue of Muscle and Nerve.
The PI is Georgirene Vladutiu, Ph.D., UB professor of pediatrics, neurology and pathology. She also directs the Robert Guthrie Biochemical Genetics Laboratory at the Women and Children's Hospital of Buffalo and specializes in the laboratory diagnosis of metabolic muscle diseases.
A couple of comments from her:
"Soldiers serving now are exposed to different environmental triggers. In addition, our sample is small. We need to prove or disprove these findings in a larger group of veterans from different theaters of war.""If the results show a specific association only in veterans of the first Gulf War, then there was likely an environmental factor, such as one or more chemical exposures that, combined with variations in the ACE gene, predisposed certain individuals to the development of medically unexplained chronic fatigue."
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Tracked on April 8, 2006 4:12 PM
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